[Users-list] metasite/grid

[Gabriele Cruciani]

Ben
I do not think it make any (pragmatic) sense.
We will not be able to change our CYP enzyme (in our body) anyway.
Probably you suggested that to 'understand'  the role of particular 
aminoacid
in the CYP structure(s). However, CYPs are promiscuous enzymes,
and the in silico site direct mutagenesis approach, at least here, will not
work (in my opinion).

Nice Christmas
Gabry

Lewis, Ben (FMC) ha scritto:

>Yes that's correct Gabry.
>
>Benjamin Lewis BSc (Hons) MRACI
>Chartered Chemist
> 
>Research Associate/PhD candidate
>Department of Clinical Pharmacology,
>School Of Medicine,
>Flinders University
>Bedford Park
>South Australia 5042
>Australia
> 
>T +61 88204 4795
>F +61 88204 5114
>E ben.lewis at fmc.sa.gov.au
>W http://som.flinders.edu.au/FUSA/ClinPharm/
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>-----Original Message-----
>From: users-list-bounces at moldiscovery.com
>[mailto:users-list-bounces at moldiscovery.com] On Behalf Of Gabriele
>Cruciani
>Sent: Saturday, 17 December 2005 01:10
>To: Support and general discussions
>Subject: Re: [Users-list] metasite/grid
>
>Hi Ben ...
>do you mean CYP Protein residues?
>Gabry
>
>
>Lewis, Ben (FMC) ha scritto:
>
>  
>
>>Firstly, hi to all subscribers of this list; I have just joined up...
>>
>>Question:
>>
>>I was wondering if anyone uses MetaSite or Grid to determine what 
>>residues to mutate to get better turnover of a drugs metabolism?
>>
>>Kind regards,
>>
>>**Benjamin Lewis BSc (Hons) MRACI**
>>
>>//Chartered Chemist//
>>
>>Research Associate/PhD candidate
>>
>>Department of Clinical Pharmacology,
>>
>>School Of Medicine,
>>
>>Flinders University
>>
>>Bedford Park
>>
>>South Australia 5042
>>
>>Australia
>>
>>//T//** **+61 88204 4795
>>
>>//F// +61 88204 5114
>>
>>//E// ben.lewis at fmc.sa.gov.au <mailto:ben.lewis at fmc.sa.gov.au>
>>
>>//W// http://som.flinders.edu.au/FUSA/ClinPharm/
>>
>>/The contents of this email are intended only for the named recipient 
>>and may be confidential. If you have received this communication in 
>>error, please contact us then delete the email and any attachments. 
>>You must not copy, distribute or disclose this message or any part of 
>>it to anyone/.
>>
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